5-Hydroxytryptophan
What is it? Overview Usage Side Effects and Warnings
Answers
askAsk

5-Hydroxytryptophan Side Effects and Warnings

Written by sshowalter, FoundHealth.

5-HTP should not be used in combination with antidepressants, monoamine oxidase inhibitors (MAOI) or herbs that have MAOI activity. 4

As Tryptophan is sometimes recommended for relieving insomnia, it may cause some drowsiness.

Some users have reported nausea in the first few days of usage, but it typically goes away.

References

  1. Sternberg EM, Van Woert MH, Young SN, Magnussen I, Baker H, Gauthier S, Osterland CK. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med. 303(14):782-7.
  2. Gwaltney-Brant SM, Albretsen JC, Khan SA. 5-Hydroxytryptophan toxicosis in dogs: 21 cases (1989-1999). J Am Vet Med Assoc. 216(12):1937-40.
  3. Coleman M. Myoclonus in the young after 5-hydroxytryptophan [letter]. N Engl J Med. 1977;296:820.
  4. De Giorgis G, Miletto R, Iannuccelli M, Camuffo M, Scerni S. Headache in association with sleep disorders in children: a psychodiagnostic evaluation and controlled clinical study--L-5-HTP versus placebo. Drugs Exp Clin Res. 13(7):425-33.
  5. Klarskov K, Johnson KL, Benson LM, Gleich GJ, Naylor S. Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan. Adv Exp Med Biol. 467():461-8.
  6. Belongia EA, Hedberg CW, Gleich GJ, White KE, Mayeno AN, Loegering DA, Dunnette SL, Pirie PL, MacDonald KL, Osterholm MT. An investigation of the cause of the eosinophilia-myalgia syndrome associated with tryptophan use. N Engl J Med. 323(6):357-65.
  7. Castot A, Bidault I, Bournerias I, Carlier P, Efthymiou ML. ["Eosinophilia-myalgia" syndrome due to L-tryptophan containing products. Cooperative evaluation of French Regional Centers of Pharmacovigilance. Analysis of 24 cases] Therapie. 46(5):355-65.
  8. Ito J, Hosaki Y, Torigoe Y, Sakimoto K. Identification of substances formed by decomposition of peak E substance in tryptophan. Food Chem Toxicol. 1992;30:71-81.
  9. Martin RW, Duffy J, Engel AG, Lie JT, Bowles CA, Moyer TP, Gleich GJ. The clinical spectrum of the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. Clinical features in 20 patients and aspects of pathophysiology. Ann Intern Med. 113(2):124-34.
  10. Mayeno AN, Lin F, Foote CS, et al. Characterization of “peak E,” a novel amino acid associated with eosinophilia-myalgia syndrome. Science. 1990;250:1707-1708.
  11. Toyo'oka T, Yamazaki T, Tanimoto T, Sato K, Sato M, Toyoda M, Ishibashi M, Yoshihira K, Uchiyama M. Characterization of contaminants in EMS-associated L-tryptophan samples by high-performance liquid chromatography. Chem Pharm Bull (Tokyo). 39(3):820-2.
  12. Trucksess MW, Thomas FS, Page SW. High-performance liquid chromatographic determination of 1,1'-ethylidenebis(L-tryptophan) in L-tryptophan preparations. J Pharm Sci. 83(5):720-2.
  13. Trucksess MW. Separation and isolation of trace impurities in L-tryptophan by high-performance liquid chromatography. J Chromatogr. 630(1-2):147-50.
  14. Das YT, Bagchi M, Bagchi D, Preuss HG. Safety of 5-hydroxy-L-tryptophan. Toxicol Lett. 150(1):111-22.
 
Share

0 Comments

No one has made any comments yet. Be the first!

Your Comment