Amitriptyline and Perphenazine Overview
(a mee TRIP ti leen & per FEN a zeen)
Created: 2006-10-13 10:36:36.0
Modified: 2010-03-19 13:18:42.0
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Canadian Brand Names
• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
How does it work?
• Amitriptyline increases chemicals in the brain.
• Perphenazine helps clear your thinking.
• In depression, sleep and appetite may improve quickly. Other depressive symptoms may take up to 4-6 weeks to improve.
How is it best taken?
• Take this medicine with or without food. Take with food if it causes an upset stomach.
• Drink plenty of noncaffeine-containing liquid unless told to drink less liquid by healthcare provider.
How should I store this medicine?
• Store at room temperature.
• Protect from light.
• Protect from moisture. Do not store in a bathroom or kitchen.
Antidepressant, Tricyclic (Tertiary Amine); Antipsychotic Agent, Typical, Phenothiazine
Reasons not to take this medicine
• If you have an allergy to amitriptyline, perphenazine, or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have any of the following conditions: Bone marrow disease, glaucoma, severe heart disease, or severe liver disease.
• If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this medicine is started. Taking the two together could cause dangerously high blood pressure.
• If you are pregnant or may be pregnant.
• If you are breast-feeding.
What do I do if I miss a dose? (does not apply to patients in the hospital)
• Take a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
• Do not change dose or stop medicine. Talk with healthcare provider.
What key warnings should I know about before taking this medicine?
• The desire to harm yourself is a serious symptom of depression. It may last until your depression is completely treated. If you are planning on harming yourself, call the emergency department right away.
• There is an increased chance of death in elderly people who take this medicine for dementia.
• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.
• Please read the medication guide.
What should I monitor?
• Change in condition being treated. Is it better, worse, or about the same?
• Dry mouth may cause an increase in cavities. Take good care of your teeth. See a dentist regularly.
• Follow up with healthcare provider.