Autism and Vitamin B6 and Magnesium
Effect of Vitamin B6 and Magnesium on Autism
It has been suggested that combining magnesium with vitamin B6 could offer additional benefits, such as reducing side effects or allowing a reduced dose of the vitamin.
Research Evidence on Vitamin B6 and Magnesium
A double-blind, placebo-controlled, crossover study found indications that very high doses of vitamin B6 may produce beneficial effects in the treatment of autism spectrum disorder.10 Again, however, this study was small and poorly designed; furthermore, it used a dose of vitamin B 6 so high that it could cause toxicity.However, the two reasonably well-designed studies using combined vitamin B 6 and magnesium have failed to find benefits.11–13 Therefore, it isn’t possible at present to recommend vitamin B 6 with or without magnesium as a treatment for autism spectrum disorder.
- Rimland B, Callaway E, Dreyfus P. The effect of high doses of vitamin B 6 on autistic children: a double-blind crossover study. Am J Psychiatry. 1978;135:472–475.
- Nye C, Brice A. Combined vitamin B 6 -magnesium treatment in autism spectrum disorder (Cochrane Review). Cochrane Database Syst Rev. 2002:CD003497.
- Findling RL, Maxwell K, Scotese-Wojtila L, et al. High-dose pyridoxine and magnesium administration in children with autistic disorder: an absence of salutary effects in a double-blind, placebo-controlled study. J Autism Dev Disord. 1997;27:467–478.
- Tolbert L, Haigler T, Waits MM, et al. Brief report: lack of response in an autistic population to a low dose clinical trial of pyridoxine plus magnesium. J Autism Dev Disord. 1993;23:193–199.