Beta-Sitosterol
What is it? Overview Usage Side Effects and Warnings
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Beta-Sitosterol Overview

Written by FoundHealth.

Numerous plants contain cholesterol-like compounds called sitosterols and their close relatives sitosterolins. A special mixture of these called beta-sitosterol is used for the treatment of benign prostatic hyperplasia (BPH) .

What Is the Scientific Evidence for Beta-Sitosterol?

A review of the literature, published in 1999, found a total of four double-blind placebo-controlled studies on beta-sitosterol for BPH, enrolling a total of 519 men. 1 2 3 All but one of these studies found significant benefits in both perceived symptoms and objective measurements, such as urine flow rate.

The largest study followed 200 men with BPH for a period of 6 months. 4 After the trial was completed, many of the participants were followed for an additional year, during which the benefits continued. 5 Similar results were seen in a 6-month, double-blind trial of 177 individuals. 6 Beta-sitosterol binds to prostate tissue and affects the metabolism of prostaglandins, substances found in the body that affect pain and inflammation. 7 However, it is not clear whether this is the correct explanation for how beta-sitosterol might help in BPH.

Dosage

The daily dosage of beta-sitosterol is 60 to 135 mg. Effects usually take 4 weeks to develop.

References

  1. Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int. 83(9):976-83.
  2. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group. Br J Urol. 1997;80:427-432.
  3. Kadow C, Abrams PH. A double-blind trial of the effect of beta-sitosteryl glucoside (WA184) in the treatment of benign prostatic hyperplasia. Eur Urol. 12(3):187-9.
  4. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet. 1995;345:1529-1532.
  5. Berges RR, Kassen A, Senge T. Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up. BJU Int. 85(7):842-6.
  6. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group. Br J Urol. 1997;80:427-432.
  7. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physicians' Guide to Herbal Medicine. 3rd ed. Berlin, Germany: Springer-Verlag; 1998:231.
 
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