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Bipolar Disorder and Choline

Read more about Choline.


Lacking choline in one's diet may be the cause of certain health conditions. Therefore, supplementing choline so that the person has adequate levels can sometimes help.

Effect of Choline on Bipolar Disorder

Only weak evidence suggests choline for the treatment of depression.6

Side Effects and Warnings

#Safety Issues

The tolerable upper intake of choline has been set at 3.5 g daily for adults. Tolerable upper intake is defined as: the highest daily intake over a prolonged time known to pose no risks to most members of a healthy population.

In higher dosages, minor but annoying side effects may occur, such as abdominal discomfort, diarrhea, and nausea. Maximum safe dosages for young children, pregnant or nursing women, or those with severe liver or kidney disease have not been determined.


  1. Vazquez I, Aguera-Ortiz LF. Herbal products and serious side effects: a case of ginseng-induced manic episode. Acta Psychiatr Scand. 2002;105:76-77.