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L-carnitine in its three forms appears to be quite safe. However, individuals with low or borderline-low thyroid levels should avoid carnitine because it might impair the action of thyroid hormone. 1 Individuals on dialysis should not receive this (or any other supplement) without a physician's supervision.
The maximum safe dosages for young children, pregnant or nursing women, or those with severe liver or kidney disease have not been established.
Interactions You Should Know About
If you are taking:
- Antiseizure medications, particularly valproic acid (Depakote, Depakene) but also phenytoin (Dilantin) : You may need extra carnitine.
- Thyroid medication: Do not take carnitine except under a physician's supervision.
- Benvenga S, Lakshmanan M, Trimarchi F. Carnitine is a naturally occurring inhibitor of thyroid hormone nuclear uptake. Thyroid. 10(12):1043-50.