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Effect of Chinese Skullcap on Asthma
The root of this plant has been used in Traditional Chinese Medicine (TCM) for a variety of conditions including asthma. Chinese skullcap contains flavone derivatives including baicalin, wogonin and...
Read more about Asthma and Chinese Skullcap.
What is Chinese Skullcap Used for Today?
The root of Chinese scullcap contains the flavonoids baicalin, wogonin, and baicalein, and most studies have involved these substances rather than the whole herb.
Highly preliminary evidence suggest that baicalin can enhance the activity of antibiotics against antibiotic-resistant staph bacteria. 1 2 Other highly preliminary evidence suggests that baicalin, wogonin, and baicalein may have anti-cancer , 3 4 5 6 anti-inflammatory, 7 liver-protective , 8 anti-anxiety , 9 and antihypertensive effects . 10 However, for none of these uses does the evidence approach the level necessary to truly establish a treatment as effective.
Research involving combination herbal therapies containing Chinese skullcap are discussed in the Traditional Chinese Herbal Medicine article.
- Liu IX, Durham DG, Richards RM. Baicalin synergy with beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus and other beta-lactam-resistant strains of S. aureus. J Pharm Pharmacol. 2000;52:361-366.
- Wang J, Yu Y, Hashimoto F, Sakata Y, Fujii M, Hou DX. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Int J Mol Med. 14(4):627-32.
- Bonham M, Posakony J, Coleman I, et al. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res. 2005;11:3905-3914.
- Liu JJ, Huang TS, Cheng WF, Lu FJ. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. Int J Cancer. 106(4):559-65.
- Wozniak D, Lamer-Zarawska E, Matkowski A, et al. Antimutagenic and antiradical properties of flavones from the roots of Scutellaria baicalensis Georgi. Nahrung. 2004;48:9-12.
- Ong ES, Len SM, Lee AC, et al. Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry. J AgricFood Chem. 2005;53:8-16.
- Chi YS, Lim H, Park H, Kim HP. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem Pharmacol. 66(7):1271-8.
- Jang SI, Kim HJ, Hwang KM, Jekal SJ, Pae HO, Choi BM, Yun YG, Kwon TO, Chung HT, Kim YC. Hepatoprotective effect of baicalin, a major flavone from Scutellaria radix, on acetaminophen-induced liver injury in mice. Immunopharmacol Immunotoxicol. 25(4):585-94.
- Liao JF, Hung WY, Chen CF. Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. Eur J Pharmacol. 464(2-3):141-6.
- Huang Y, Tsang SY, Yao X, Chen ZY. Biological properties of baicalein in cardiovascular system. Curr Drug Targets Cardiovasc Haematol Disord. 5(2):177-84.