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Chronic Fatigue Syndrome (CFS) and Atypical Antidepressants

Read more about Atypical Antidepressants.

Effect of Atypical Antidepressants on Chronic Fatigue Syndrome (CFS)

Another class of antidepressants that might be prescribed for the treatment of chronic fatigue syndrome are atypical antidepressants.

Common names include:

  • Trazodone (Desyrel)
  • Venlafaxine (Effexor)
  • Bupropion (Wellbutrin)

Atypical antidepressants are used to treat the depression that may accompany CFS. Improvement is usually seen in four to six weeks after beginning treatment.

Side Effects and Warnings

Possible side effects include:

  • Nausea
  • Nervousness
  • Diminished sex drive
  • Risk of severe mood and behavior changes
  • Suicidal thoughts and behaviors (Young adults may be at a higher risk for this side effect.)

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