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Chronic Fatigue Syndrome (CFS) and Nicotinamide Adenine Dinucleotide

Read more about Nicotinamide Adenine Dinucleotide.


Nicotinamide adenine dinucleotide (NADH) is a naturally occurring chemical that plays a significant role in cellular energy production.

Effect of Nicotinamide Adenine Dinucleotide on Chronic Fatigue Syndrome (CFS)

Nicotinamide Adenine Dinucleotide supplements have been tried in hopes they might improve energy levels in athletes and in individuals with chronic fatigue, as they work to help with cellular energy production.

Research Evidence on Nicotinamide Adenine Dinucleotide

A double-blind, placebo-controlled crossover trial that followed 26 people given 10 mg of NADH for a 4-week period showed some improvement in symptoms during NADH treatment as compared to the period of placebo treatment (31% versus 8%).17 However, larger studies will have to be performed to actually prove a benefit with this supplement.

Side Effects and Warnings

#Safety Issues

NADH appears to be quite safe when taken at a dosage of 5 mg daily or less. However, formal safety studies have not been completed, and safety in young children, pregnant or nursing women, or those with severe liver or kidney disease has not been established.


  1. Forsyth LM, Preuss HG, MacDowell AL, et al. Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome. Ann Allergy. 1999;82:185-191.