Citrus Bioflavonoids
What is it? Overview Usage Side Effects and Warnings

Citrus Bioflavonoids Side Effects and Warnings

Written by FoundHealth.

Safety Issues

Extensive investigations of diosmin and hesperidin have found them to be essentially nontoxic and free of drug interactions. 1 The combination has been given to 50 pregnant women in a research study, without apparent harm to mothers or babies. 2 Some evidence suggests that the bioflavonoid naringen may interact with medications in the calcium channel blocker family, increasing blood levels of the drug. 3 This may necessitate a reduction in drug dosage.

The citrus bioflavonoid tangeretin may reduce the effectiveness of tamoxifen , a drug used to treat breast cancer. 4 One highly preliminary study suggests that some citrus bioflavonoids in the diet of pregnant women might increase the risk of infant leukemia; hesperidin did not produce this effect, and diosmin was not tested. 5

Interactions You Should Know About

If you are taking:

  • Calcium channel blockers : Use of the bioflavonoid naringen may necessitate a reduction in medication dose.
  • Tamoxifen for breast cancer: You should avoid citrus fruits and juices and the citrus bioflavonoid tangeretin.


  1. Meyer OC. Safety and security of Daflon 500 mg in venous insufficiency and in hemorrhoidal disease. Angiology. 45(6 Pt 2):579-84.
  2. Buckshee K, Takkar D, Aggarwal N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet. 57(2):145-51.
  3. Yeum CH, Choi JS. Effect of naringin pretreatment on bioavailability of verapamil in rabbits. Arch Pharm Res. 29(1):102-7.
  4. Bracke ME, Depypere HT, Boterberg T, Van Marck VL, Vennekens KM, Vanluchene E, Nuytinck M, Serreyn R, Mareel MM. Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. J Natl Cancer Inst. 91(4):354-9.
  5. Strick R, Strissel PL, Borgers S, et al. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc Natl Acad Sci. 2000;97:4790-4795.


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