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Hot flashes and premenstrual-type symptoms such as migraine headaches and breast discomfort may occur with clomiphene use. Notify your doctor if you experience:
- visual symptoms such as spots, flashes, blurred vision
- nausea and vomiting
- abnormal uterine bleeding
- ovarian enlargement which may present as abdominal or pelvic pain, tenderness, pressure, or swelling;
Patients taking Clomiphene may suffer from a serious condition known as ovarian hyperstimulation syndrome (OHSS). Its symptoms include swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, and nausea or vomiting. If you develop any of these side effects, you should inform your doctor immediately or seek emergency medical care.
Clomiphene binds to your estrogen receptors, including the estrogen receptors in the cervix. This can interfere with the cervical mucus to make fertile mucus. Lack of fertile cervical mucus on the days after ovulation can interfere with sperm penetration into the uterus and fallopian tubes.
Clomiphene is metabolized by the liver, therefore, you can not take clomiphene if you have liver disease. Clomiphene use may result in ovarian hyperstimulation, thus enlarged ovaries, ovarian cysts, or polycystic ovaries are considered as relative contraindications.
When to Discontinue Clomiphene?
Stop taking Clomiphen and seek emergency care if you experience symptoms of an allergic reaction, such as:
- swelling of your lips, tongue, or face;
- difficulty breathing or
You should stop taking Clomiphene if pregnancy does not occur within 3 or 4 months of drug treatment. You need to consult a fertility specialist about other treatment options.