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The safety of detoxification methods varies widely. While drinking a quart of water a day is undoubtedly benign and mercury-filling removal is unlikely to harm anything but one’s pocketbook, other methods might be risky. High colonics have occasionally resulted in serious internal injury, and intravenous therapies, being highly invasive, must be handled with a certain degree of sophistication to avoid causing harm. Considering that detoxification has not been proven useful, we recommend sticking to the more moderate of its various methods if you wish to try it at all.