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DIM is thought to be a relatively nontoxic substance. However, comprehensive safety studies have not been completed. Due to DIM’s complex interactions with estrogen and testosterone, it has the potential for causing hormonal disturbances. Safety in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.
Although there are no known drug interactions with DIM, the substance has shown considerable potential for interacting with many medications. 1 2 For this reason, we recommend that if you use any medication that is critical for your health, do not use DIM except under a physician's supervision.
- Katchamart S, Stresser DM, Dehal SS, Kupfer D, Williams DE. Concurrent flavin-containing monooxygenase down-regulation and cytochrome P-450 induction by dietary indoles in rat: implications for drug-drug interaction. Drug Metab Dispos. 28(8):930-6.
- Lake BG, Tredger JM, Renwick AB, Barton PT, Price RJ. 3,3'-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica. 28(8):803-11.