What is it? Overview Usage Side Effects and Warnings

What is Diindolylmethane?

Diindolylmethane (DIM) is produced when the substance indole-3-carbinol (I3C) is digested. Indole-3-carbinol, found in broccoli and other vegetables, has shown considerable promise for cancer prevention . Some of its benefits in this regard may occur after it is converted by the body to DIM.

DIM also has complex interactions with the hormone estrogen, which could lead to either positive or negative effects on cancer risk.

Numerous test-tube and animal studies hint that DIM is might help prevent various types of cancer, especially breast, cervical, prostate, and uterine cancer. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 However, this evidence is far too preliminary to serve as the basis for recommending that anyone use DIM. As with many proposed cancer-preventing substances, there are also circumstances in which DIM might actually increase the risk of cancer. 16 17 Some of DIM’s apparent anticancer benefits appear to derive from its complex interactions with estrogen. 18 19 20 21 22 23 24 DIM appears to alter liver function in such a manner that an increased amount of estrogen becomes metabolized into inactive forms. In addition, DIN...

Safety Issues

DIM is thought to be a relatively nontoxic substance. However, comprehensive safety studies have not been completed. Due to DIM’s complex interactions with estrogen and testosterone, it has the potential for causing hormonal disturbances. Safety in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.

Although there are no known drug interactions with DIM, the substance has shown considerable potential for interacting with many medications. 25 26 For this reason, we recommend that if you use any medication that is critical for your health, do not use DIM except under a physician's supervision.