What is it? Overview Usage Side Effects and Warnings

DMAE Overview

Written by FoundHealth.

DMAE (2-dimethylaminoethanol) is a chemical that has been used to treat a number of conditions affecting the brain and central nervous system. Like other such treatments, it is thought to work by increasing production of the neurotransmitter acetylcholine, although this has not been proven.


DMAE is sold in pharmacies and healthfood stores, as well as on the Internet, as a nutritional supplement.

Therapeutic Dosages

Manufacturers' recommended dosages and those used in clinical studies vary between 400 and 1,800 mg daily.

What Is the Scientific Evidence for DMAE?

Attention Deficit Hyperactivity Disorder (ADHD)

There is some evidence that DMAE may be helpful for attention deficit hyperactivity disorder (ADHD) , according to studies performed in the 1970s. Two such studies were reported in a review article on DMAE. 1 Fifty children aged 6 to 12 years who had been diagnosed with hyperkinesia (their diagnosis today would likely be ADHD) participated in a double-blind study comparing DMAE to placebo. The dose was increased from 300 mg daily to 500 mg daily by the third week, and continued for 10 weeks. Evaluations revealed statistically significant test score improvements in the treatment group compared to the placebo group.

Another double-blind study compared DMAE with both methylphenidate (Ritalin) and placebo in 74 children described as having unspecified "learning disabilities" (also probably what we would call ADHD today). 2 The study found significant test score improvement for both treatment groups over a 10-week period. Positive results were also seen in a small open study . 3

Alzheimer's Disease

Most people over the age of 40 experience some memory loss, but Alzheimer's disease is much more serious, leading to severe mental deterioration (dementia) in the elderly. Microscopic examination shows that in the areas of the brain involved in higher thought processes, nerve cells have died and disappeared, particularly cells that release the chemical acetylcholine. Drugs such as tacrine and danazol, and supplements such as huperzine A , are used for Alzheimer's based on their ability to increase acetylcholine levels. Because DMAE is also thought to increase acetylcholine, trials have been performed to test its effectiveness for the same purpose. However, there is no real evidence as yet that it works.

A double-blind, placebo-controlled study involving 27 patients with Alzheimer's disease tested DMAE as a treatment. 4 Thirteen participants were placed in the group receiving DMAE; however, six of them had to drop out of the study because of side effects such as drowsiness, increased confusion, and elevated blood pressure. In those completing the trial, no differences were seen between the treatment group and those taking placebo.

An open trial enrolling 14 patients found no improvement in either memory or cognitive function. The researchers did note improvements in symptoms of depression. But, in the absence of a placebo group, this observation means little. 5

Tardive Dyskinesia

Tardive dyskinesia (TD) is a potentially permanent side effect of drugs used to control schizophrenia . This late-developing (tardy, or tardive) complication consists of annoying, uncontrollable movements (dyskinesias), particularly in the face.

Based on its supposed cholinergic effect, DMAE has been proposed as a treatment for TD. Although some case reports and open studies seem to suggest that DMAE might be useful for this purpose, 6 properly designed studies using double-blind methods and placebo control groups have not borne this out. Of 12 double-blind studies reviewed, only one found DMAE to be significantly effective when compared with placebo. 7 A meta-analysis of proposed treatments for TD found DMAE to be no more effective than placebo. 8 It seems likely, though not entirely certain, that the benefits seen in open studies and individual cases were the result of a placebo effect. However, it is also possible that some particular individuals respond well to DMAE, even if most don't.

Huntington's Chorea

Huntington's chorea is a genetically inherited disease that results in personality changes and, somewhat similarly to TD, uncontrolled spastic movements. It doesn't usually become symptomatic until a person's age reaches the late thirties or older, although about 10% of people with Huntington's will begin to show signs of the disorder in childhood or adolescence.

DMAE was not found to be an effective treatment for Huntington's chorea in double-blind, placebo-controlled trials, although mixed results have been obtained using DMAE in open trials. 9


  1. Re' O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp. 16(11):1238-42.
  2. Re' O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp. 16(11):1238-42.
  3. Knobel M. Approach to a combined pharmacologic therapy of childhood hyperkinesis. Behav Neuropsychiatry. 6(1-12):87-90.
  4. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer’s disease. Am J Psychiaty. 1981;138:970-972.
  5. Ferris SH, Sathananthan G, Gershon S, Clark C. Senile dementia: treatment with deanol. J Am Geriatr Soc. 25(6):241-4.
  6. Casey DE, Denney D. Dimethylaminoethanol in tardive dyskinesia [letter]. N Engl J Med. 1974;291:797.
  7. Alphs L, Davis JM. Noncatecholaminergic treatments of tardive dyskinesia. J Clin Psychopharmacol. 2(6):380-5.
  8. Soares KV, McGrath JJ. The treatment of tardive dyskinesia--a systematic review and meta-analysis. Schizophr Res. 39(1):1-16; discussion 17-8.
  9. Caraceni TA, Girotti F, Celano I, Parati E, Balboni L. 2-dimethylaminoethanol (Deanol) in Huntington's chorea. J Neurol Neurosurg Psychiatry. 41(12):1114-8.


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