Estradiol and Levonorgestrel Overview
(es tra DYE ole & LEE voe nor jes trel)
Created: 2006-10-13 12:21:24.0
Modified: 2010-04-07 10:24:21.0
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• If you have a life-threatening allergy, wear allergy identification at all times.
• Do not share your medicine with others and do not take anyone else's medicine.
• Keep all medicine out of the reach of children and pets.
• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.
• Read the package insert for more details.
How does it work?
• When the body no longer produces estrogen, this medicine is used as an estrogen replacement.
• Levonorgestrel is a progesterone used to reduce endometrial cell changes and the risk of endometrial cancer.
How is it best taken?
• Apply to clean, dry, healthy skin on lower belly. Move site with each patch.
• Do not place on breast. Place below waistline.
• Follow diet plan and exercise program as recommended by healthcare provider.
How should I store this medicine?
• Store at room temperature.
Estrogen and Progestin Combination
Reasons not to take this medicine
• If you have an allergy to estradiol, levonorgestrel, or any other part of this medicine.
• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
• If you have any of the following conditions: Blood clots, breast cancer, stroke, tumor where estrogen makes it grow, or unexplained vaginal bleeding.
• If you have major surgery and need bedrest.
• If you turned yellow during pregnancy or with estrogen-based or hormone contraceptive use.
U.S. Brand Names
What do I do if I miss a dose? (does not apply to patients in the hospital)
• Use a missed dose as soon as possible.
• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
• Do not take a double dose or extra doses.
What key warnings should I know about before taking this medicine?
• Estrogens, when used in females after menopause, may increase the risk of uterine cancer. Progestins may decrease this risk. A warning sign for cancer of the uterus is unusual vaginal bleeding. Report any unusual vaginal bleeding to healthcare provider.
• Do not take estrogens to prevent heart disease or dementia. Using estrogens may increase your chances of having a heart attack, a stroke, breast cancer, or a blood clot.
• This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.
What should I monitor?
• Change in condition being treated. Is it better, worse, or about the same?
• If you are taking a blood thinner, check blood work (prothrombin time/INR). Talk with healthcare provider.
• Check blood pressure and heart rate regularly. Talk with healthcare provider.
• If you are diabetic, you will need to monitor blood sugars closely.
• Check blood work (cholesterol panel). Talk with healthcare provider.
• Have a yearly eye exam.
• Bone density test.
• Periodic breast (monthly self-exam) and yearly gynecologic exams are important.
• Follow up with healthcare provider yearly.