Estramustine Side Effects and Warnings

What are the precautions when taking this medicine?

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• If you have diabetes, talk with healthcare provider.

• If you have high blood pressure, talk with healthcare provider.

• If you have kidney disease, talk with healthcare provider.

• If you have liver disease, talk with healthcare provider.

• If you have had a stroke, talk with healthcare provider.

• If you have a weakened heart, talk with healthcare provider.

• If you are a male and sexually active, protect your partner from pregnancy. Use birth control that you can trust.

• Talk with healthcare provider before receiving any vaccinations. Use with this medicine may either increase the risk of serious infection or make the vaccination less effective.

What are some possible side effects of this medicine?

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Diarrhea.

• Swelling.

• Breast tenderness.

• Breast enlargement.

• Change in sexual ability or desire. This is usually reversible.

• Leg cramps.

• Heart damage can rarely occur.

• Liver damage can rarely occur.

• Lung damage can rarely occur.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.

• Chest pain or pressure or fast heartbeat.

• Difficulty breathing.

• Severe nausea or vomiting.

• Severe diarrhea.

• Swelling or pain of leg or arm.

• Severe headache.

• Unusual bruising or bleeding.

• Severe skin irritation.

• Any rash.

• No improvement in condition or feeling worse.