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Most of the safety information we have regarding GLA comes from experience with evening primrose oil.
Animal studies suggest that evening primrose oil is completely nontoxic and noncarcinogenic. 1 More than 4,000 people have taken GLA or evening primrose oil in scientific studies, and no significant adverse effects have ever been noted.
Early reports suggested the possibility that GLA might worsen temporal lobe epilepsy, but there has been no later confirmation. 2 The maximum safe dosage of GLA for young children, pregnant or nursing women, or those with severe liver or kidney disease has not been established.
- Horrobin DF. Nutritional and medical importance of gamma-linolenic acid. Prog Lipid Res. 31(2):163-94.
- Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med. 6(4):375-9.