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In the late 1970s, a batch of rice bran oil was contaminated by PCBs (polychlorobiphenyls), resulting in the poisoning of more than 2,000 people. This led to studies on the safety of gamma oryzanol products. On balance, the results of these investigations suggest that gamma oryzanol, when taken at normal doses, is nontoxic and noncarcinogenic. 1 However, the maximum safe dosages for young children, pregnant or nursing women, or those with severe liver or kidney disease have not been established.
- Cicero AF, Gaddi A. Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions. Phytother Res. 15(4):277-89.