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Heartburn/GERD and Proton Pump Inhibitors

Read more about Proton Pump Inhibitors.

[Edit] [Revisions] [Writers] Overview

Proton pump inhibitors (PPI) are very potent acid-suppressing drugs that are usually prescribed for people with more severe or persistent GERD. PPI's stop cells in the lining of the stomach from making too much acid. This can help prevent ulcer formation and facilitates healing.

[Edit] [Revisions] [Writers] Effect of Proton Pump Inhibitors on Heartburn/GERD

Proton pump inhibitors’ work by blocking a chemical system which is responsible for making stomach acid. This is known as the hydrogen-potassium adenosine triphosphatase enzyme system (proton pump).The proton pump is a molecule in the parietal cells of the stomach which is known to "pump" acid. The proton pump takes a non-acidic potassium ion out of the stomach and replaces it with an acidic hydrogen ion. This hydrogen ion makes substances acidic. By adding more hydrogen ions into your stomach, the proton pump makes the stomach content more acidic. Inhibiting the action of the pump, thereby stops acid production.

[Edit] [Revisions] [Writers] References

  1. Anthony, P.,Delmar's Pharmacy Technician Certification Exam Review. 2nd Edition. 2003. Delmar Cengage Learning.
  2. Rosenthal. M. 50 Ways to Relieve Heartburn, Reflux and Ulcers. 2001. McGraw-Hill
  3. http://www.mayoclinic.com/health/drug-information/DR601471
  4. http://www.purplepill.com/about-nexium/index.aspx
  5. http://www.drugs.com/omeprazole.html
  6. http://www.drugs.com/nexium.html