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Heartburn/GERD and Proton Pump Inhibitors

Read more about Proton Pump Inhibitors.


Proton pump inhibitors (PPI) are very potent acid-suppressing drugs that are usually prescribed for people with more severe or persistent GERD. PPI's stop cells in the lining of the stomach from making too much acid. This can help prevent ulcer formation and facilitates healing.

Effect of Proton Pump Inhibitors on Heartburn/GERD

Proton pump inhibitors’ work by blocking a chemical system which is responsible for making stomach acid. This is known as the hydrogen-potassium adenosine triphosphatase enzyme system (proton pump).The proton pump is a molecule in the parietal cells of the stomach which is known to "pump" acid. The proton pump takes a non-acidic potassium ion out of the stomach and replaces it with an acidic hydrogen ion. This hydrogen ion makes substances acidic. By adding more hydrogen ions into your stomach, the proton pump makes the stomach content more acidic. Inhibiting the action of the pump, thereby stops acid production.


Effect of Omeprazole on Heartburn/GERD

Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. It is also used to promote healing of erosive...

Read more about Heartburn/GERD and Omeprazole.

Effect of Esomeprazole on Heartburn/GERD

Esomeprazole is prescribed to treat the symptoms of acid reflux disease and to heal acid-related damage to the esophagus. It is also used with other drugs to prevent stomach ulcers. Like other proton...

Read more about Heartburn/GERD and Esomeprazole.


  1. Anthony, P.,Delmar's Pharmacy Technician Certification Exam Review. 2nd Edition. 2003. Delmar Cengage Learning.
  2. Rosenthal. M. 50 Ways to Relieve Heartburn, Reflux and Ulcers. 2001. McGraw-Hill