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Lignans Side Effects and Warnings

Side Effects and Warnings

#Safety Issues

Women who are pregnant or breastfeeding should avoid high intake of flaxseed or purified lignans. One study found that pregnant rats who ate large amounts of flaxseed (5% or 10% of their diet), or a purified lignan present in flaxseed, gave birth to offspring with altered reproductive organs and functions, and that lignans were also transferred to the baby rats during nursing. ^[1] In humans, eating 25 g of flaxseed per day amounts to about 5% of the diet. ^[2] High intake of lignans may not be safe for women with a history of estrogen-sensitive cancer, such as breast cancer or uterine cancer. A few test tube studies suggest that certain cancer cells can be stimulated by lignans such as those present in flaxseed. ^[3] Other studies found that lignans inhibit cancer cell growth. ^[4] As with estrogen, lignans' positive or negative effects on cancer cells may depend on dose, type of cancer cell, and levels of hormones in the body. If you have a history of cancer, particularly breast cancer, talk with your doctor before consuming large amounts of flaxseeds.

Other potential concerns are discussed in the safety section of the Flaxseed article.