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Although lysine is an essential part of the diet, the safety of concentrated lysine supplements has not been well studied. In animal studies, high dosages have caused gallstones and elevated cholesterol levels, 1 so you may want to use caution when using lysine if you have either of these problems. Maximum safe dosages for young children, pregnant or nursing women, or those with severe liver or kidney disease have not been established.
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- Kritchevsky D, Weber MM, Klurfeld DM. Gallstone formation in hamsters: Influence of specific amino acids. Nutr Rep Int. 1984;29:117-121.
- Griffith RS, DeLong DC, Nelson JD. Relation of arginine-lysine antagonism to herpes simplex growth in tissue culture. Chemotherapy. 27(3):209-13.