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The body synthesizes malic acid during the process of converting carbohydrates to energy. Extremely preliminary evidence suggests that individuals with the disease fibromyalgia (a disorder that involves fatigue and pain in the muscles) might have difficulty creating or utilizing malic acid. 1 Such a deficiency could interfere with normal muscle function.
Based on this supposition, products containing malic acid and other nutrients were widely offered for sale to people with fibromyalgia. However, there is as yet no evidence that these products are in fact helpful.
Malic acid is a major ingredient in combination treatments used for fibromyalgia. However, there is no meaningful evidence that it works.
Malic acid appears to be safe at recommended dosages. A few people reported loose stools at the higher doses in the above studies, possibly due to the magnesium in the combination.
Safety in pregnant or nursing women, children, or individuals with severe liver or kidney disease has not been established.