Menopause and Black Cohosh
Effect of Black Cohosh on Menopause
Black cohosh’s main use today is for the treatment of menopausal symptoms. Some evidence indicates that black cohosh extract might reduce hot flashes as well as other symptoms of menopause.
In the past, black cohosh was believed to be a phytoestrogen, a plant-based substance that behaves in a similar way to estrogen. However, growing evidence indicates that black cohosh does not have general estrogen-like actions. Rather, it may act like estrogen only in certain places:
- the brain (reducing hot flashes)
- the bones (potentially fighting osteoporosis)
- the vagina (reducing vaginal dryness)
It does not appear to act like estrogen in the breast or the uterus. If these findings about black cohosh's effects are reliable, then black cohosh is a selective-estrogen receptor modifier (SERM) somewhat like the drug raloxifen (Evista).
Research Evidence on Black Cohosh
A 12-week, double-blind, placebo-controlled trial of 304 women with menopausal symptoms found that black cohosh was more effective than placebo in reducing number of hot flashes.
Promising results were also seen in a 3-month, double-blind study of 120 menopausal women. Participants were given either black cohosh or fluoxetine (Prozac). Over the course of the trial, black cohosh proved more effective than fluoxetine for hot flashes, but fluoxetine was more effective than black cohosh for menopause-related mood changes.
Previous smaller studies have found improvements not only in hot flashes but also in other symptoms of menopause. For example, in a double-blind, placebo-controlled study, 97 menopausal women received black cohosh, estrogen, or placebo for 3 months. The results indicated that the herb reduced overall menopausal symptoms (such as hot flashes) to the same extent as the drug. In addition, microscopic analysis showed that black cohosh had an estrogen-like effect on the cells of the vagina. This is a positive result because it suggests that black cohosh might reduce vaginal thinning. However, black cohosh did not affect the cells of the uterus in an estrogen-like manner; this too is a positive result, as estrogen’s effects on the uterus are potentially harmful. Finally, the study found hints that black cohosh might help protect bone.
A study reported in 2006 found that black cohosh has weak estrogen-like effects on vaginal cells and possible positive effects on bone. Specifically, the herb stimulated new bone formation, preventing or even possibly reversing osteoporosis.
One interesting double-blind study evaluated a combination therapy containing black cohosh and St. John's wort in 301 women with general menopausal symptoms as well as depression. The results showed that use of the combination treatment was significantly more effective than placebo for both problems.
A smaller study using a combination of the same two herbs found improvements in overall menopausal symptoms as well as cholesterol profile.
The bottom line: Black cohosh may be modestly effective for reducing hot flashes and other symptoms of menopause.
Side Effects and Warnings
Black cohosh seldom produces any side effects other than occasional mild gastrointestinal distress. One rigorous study looked for possible deleterious effects on cholesterol levels, blood sugar, and blood coagulability, and did not find any.
Studies in rats have found no significant toxicity when black cohosh was given at 90 times the therapeutic dosage for a period of 6 months. Since 6 months in a rat corresponds to decades in a human, this study appears to make a strong statement about the long-term safety of black cohosh.
Unlike estrogen, black cohosh does not stimulate breast cancer cells growing in a test tube. However, black cohosh has not yet been subjected to large-scale studies similar to those conducted for estrogen. For this reason, safety for those with previous breast cancer is not known. Also, because of potential hormonal activity, black cohosh is not recommended for adolescents or pregnant or nursing women.
There are a growing number of case reports in which it appeared that use of a black cohosh led to severe liver injury. However, it is not clear whether the cause was black cohosh itself, or a contaminant present in the product.
One highly preliminary study found that black cohosh might reduce the effectiveness of the chemotherapy drug cisplatin.
Safety in young children or those with severe liver or kidney disease is not known.
Black cohosh should not be confused with blue cohosh (Caulophyllum thalictroides), which has different properties, treatment uses, and side effects. Black cohosh is sometimes used with blue cohosh to stimulate labor, but this therapy has caused adverse effects in newborns, which appear to be due to blue cohosh.
#Interactions You Should Know About
Black cohosh might reduce the effectiveness of cisplatin.
- Stoll W. Phytotherapeutic agent affects atrophic vaginal epithelium. Double-blind study: Cimicifuga vs. an estrogen preparation [translated from German]. Therapeutikon. 1987;1:23-31.
- Liske E, Hanggi W, Henneicke-Von Zepelin HH, et al. Physiological investigation of a unique extract of black cohosh ( Cimicifugae racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect. J Womens Health Gend Based Med. 2002;11:163-174.
- Einer-Jensen N, Zhao J, Andersen KP, et al. Cimicifuga and Melbosia lack oestrogenic effects in mice and rats. Maturitas. 1996;25:149-153.
- Jacobson JS, Troxel AB, Evans J, et al. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol. 2001;19:2739-2745.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physicians' Guide to Herbal Medicine. 3rd ed. Berlin, Germany: Springer-Verlag; 1998:246.
- Warnecke G. Influencing menopausal symptoms with a phytotherapeutic agent [in German]. Med Welt. 1985;36:871-874.
- Stolze H. An alternative to treat menopausal complaints [translated from German]. Gyne. 1982;1:14-16.
- Lehmann-Willenbrock E, Riedel HH. Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestations following hysterectomy with intact adnexa [in German; English abstract]. Zentralbl Gynakol. 1988;110:611-618.
- Liske E. Therapeutic efficacy and safety of Cimicifuga racemosa for gynecologic disorders. Adv Ther. 1998;15:45-53.
- MacLennan A, Lester S, Moore V. Oral estrogen replacement therapy versus placebo for hot flushes: a systematic review. Climacteric. 2001;4:58-74.
- Seidlova-Wuttke D, Wuttke W. Selective estrogen receptor modulator activity of Cimicifuga racemosa extract: clinical data [abstract]. Phytomedicine. 2000;7(suppl 2):11.
- Seidlova-Wuttke D, Jarry H, Heiden I, et al. Effects of Cimicifuga racemosa on estrogen-dependent tissues [abstract]. Phytomedicine. 2000;7(suppl 2):11-12.
- Wuttke W, Jarry H, Heiden I, et al. Selective estrogen receptor modulator (SERM) activity of the Cimicifuga racemosa extract BNO 1055: pharmacology and mechanisms of action [abstract]. Phytomedicine. 2000;7(suppl 2):12.
- Jones TK, Lawson BM. Profound neonatal congestive heart failure caused by maternal consumption of blue cohosh herbal medication. J Pediatr. 1998;132:550-552.
- Korn WD. Six-month Oral Toxicity Study with Remifemin-granulate in Rats Followed by an 8-week Recovery Period. Hannover, Germany: International Bio-research; 1991.
- Nesselhut T, Schellhase C, Dietrich R, et al. Investigation into the growth-inhibitive efficacy of phytopharmacopia with estrogen-like influences on mammary gland carcinoma cells [translated from German]. Arch Gynecol Obstet. 1993;254:817-818.
- Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs and spices. Proc Soc Exp Biol Med. 1998;217:369-378.
- Freudenstein J, Dasenbrock C, Nisslein T. Lack of promotion of estrogen dependent mammary gland tumors in vivo by an isopropanolic black cohosh extract [abstract]. Phytomedicine. 2000;7(suppl 2):13.
- Newall C, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London, England: Pharmaceutical Press; 1996:80.
- Genazzani E, Sorrentino L. Vascular action of acteina: active constituent of Actaea racemosa L.Nature. 1962;194:544-545.
- Einer-Jensen N, Zhao J, Andersen KP, et al. Cimicifuga and Melbosia lack oestrogenic effects in mice and rats. Maturitas. 1996;25:149-153.
- Nesselhut T, Liske E. Pharmacological measures in postmenopausal women with an isopropanolic aqueous extract of Cimicifugae racemosae rhizoma.Menopause. 1999;6:1072-3714.
- Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med. 1998;217:369-378.
- Jarry H, Harnischfeger G. Endocrine effects of constituents of Cimicifuga racemosa. The effect on serum levels of pituitary hormones in ovariectomized rats. Planta Med. 1985;1:46-49.
- Wuttke W, Seidlova-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas. 2003;44(suppl 1):S67-S77.
- Whiting PW, Clouston A, Kerlin P. Black cohosh and other herbal remedies associated with acute hepatitis. Med J Aust. 2002;177:440-443.
- Osmers R, Friede M, Liske E, et al. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol. 2005;105:1074-83.
- Burdette JE, Liu J, Chen SN, et al. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agric Food Chem. 2003;51:5661-5670.
- Beck V, Unterrieder E, Krenn L, et al. Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy. J Steroid Biochem Mol Biol. 2003;84:259-268.
- Rockwell S, Liu Y, Higgins S. Alteration of the effects of cancer therapy agents on breast cancer cells by the herbal medicine black cohosh. Breast Cancer Res Treat. 2005;90:233-239.
- O'Connor AM, Merel NH, Te HS, Cohen SM. A case of autoimmune hepatitis associated with the use of black cohosh [abstract]. Am J Gastroenterol. 2003;98(9 suppl):S165.
- Wuttke W, Gorkow C, Seidlova-Wuttke D. Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study. Menopause. 2006;13:185-196.
- Nappi RE, Malavasi B, Brundu B, et al. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol. 2005;20:30-35.
- Newton K, Reed S, Grothaus L, et al.. The Herbal Alternatives for Menopause (HALT) Study: background and study design. Maturitas. 2005;16:134-146.
- Frei-Kleiner S, Schaffner W, Rahlfs VW, et al. Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial. Maturitas. 2005;51:397-404.
- Verhoeven MO, van der Mooren MJ, van de Weijer PH, et al. Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study. Menopause. 2005;12:412-20.
- Uebelhack R, Blohmer JU, Graubaum HJ, et al. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol. 2006;107:247-55.
- Wuttke W, Gorkow C, Seidlova-Wuttke D. Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study. Menopause. 2006;13:185-96.
- Jiang B, Kronenberg F, Nuntanakorn P, et al. Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry. J Agric Food Chem. 2006;54:3242-3253.
- Stromeier S, Petereit F, Nahrstedt A. Phenolic esters from the rhizomes of Cimicifuga racemosa do not cause proliferation effects in MCF-7 cells. Planta Med. 2005;71:495-500.
- Bodinet C, Freudenstein J. Influence of marketed herbal menopause preparations on MCF-7 cell proliferation. Menopause. 2004;11:281-289.
- Hostanska K, Nisslein T, Freudenstein J, et al. Cimicifuga racemosa extract inhibits proliferation of estrogen receptor-positive and negative human breast carcinoma cell lines by induction of apoptosis. Breast Cancer Res Treat. 2004;84:151-60.
- Pockaj BA, Gallagher JG, Loprinzi CL, et al. Phase III Double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1. J Clin Oncol. 2006;24:2836-2841.
- Lynch CR, Folkers ME, Hutson WR. Fulminant hepatic failure associated with the use of black cohosh: a case report. Liver Transpl. 2006;12:989-992.
- Wuttke W, Raus K, Gorkow C. Efficacy and tolerability of the Black cohosh (Actaea racemosa) ethanolic extract BNO 1055 on climacteric complaints: A double-blind, placebo- and conjugated estrogens-controlled study. Maturitas. 2006 Aug 21. [Epub ahead of print]
- Spangler L, Newton KM, Grothaus LC, et al. The effects of black cohosh therapies on lipids, fibrinogen, glucose, and insulin. Maturitas. 2007 Jan 31. [Epub ahead of print]
- Chung DJ, Kim HY, Park KH, et al. Black Cohosh and St. John's wort (GYNO-Plus®) for climacteric symptoms. Yonsei Med J. 2007;48:289-294.
- Oktem M, Eroglu D, Karahan HB, et al. Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial. Adv Ther. 2007;24:448-461.
- Bai W, Henneicke-von Zepelin HH, Wang S, et al. Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: A randomized, double blind, parallel-controlled study versus tibolone. Maturitas. 2007 Jun 21. [Epub ahead of print]
- Swanson SG, Drosman S, Helmond FA, et al. Tibolone for the treatment of moderate to severe vasomotor symptoms and genital atrophy in postmenopausal women: a multicenter, randomized, double-blind, placebo-controlled study. Menopause. 2006;13:917-925.
- Reed SD, Newton KM, Lacroix AZ, et al. Vaginal, endometrial, and reproductive hormone findings: randomized, placebo-controlled trial of black cohosh, multibotanical herbs, and dietary soy for vasomotor symptoms: the Herbal Alternatives for Menopause (HALT) Study. Menopause. 2007 Jul 6. [Epub ahead of print]
- Shahin AY, Ismail AM, Zahran KM, et al. Adding phytoestrogens to clomiphene induction in unexplained infertility patients—a randomized trial. Reprod Biomed Online. 2008;16:580-588.
- Kanadys WM, Bozena LG, Jan O. Efficacy and safety of Black cohosh ( Actaea/Cimicifuga racemosa) in the treatment of vasomotor symptoms--review of clinical trials] Ginekol Pol. 2008;79:287-96.
- Borrelli F, Ernst E. Black cohosh ( Cimicifuga racemosa) for menopausal symptoms: A systematic review of its efficacy. Pharmacol Res. 2008 Jun 8.