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Isoflavones are naturally occurring, hormonally active substances found in soy and other foods. Chemical modifications of isoflavones have been studied as possible alternative treatments for various conditions. One of these, ipriflavone , was developed primarily for treating osteoporosis . Methoxyisoflavone is a chemical derivative of ipriflavone, but it is marketed as a bodybuilding aid .
Methoxyisoflavone is marketed as an anabolic steroid, said to increase muscle mass without causing androgenic (testosterone-like) effects. However, there is no meaningful evidence that it actually works.
The use of methoxyisoflavone in the US began with two US patents established in the late 1970s. 1 The patent applications report a few research studies performed by the Hungarian pharmaceutical company Chinoin. None of these studies were published in peer-reviewed journals; furthermore, even as described, this research is altogether inadequate to demonstrate effectiveness, consisting as it did only of animal studies and exceedingly preliminary studies on humans. Proof of effectiveness is not required to establish a patent.
One placebo-controlled human trial on methoxyisoflavone...
Methoxyflavone has not undergone comprehensive safety testing. Those who take it do so at their own risk.