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Osteoarthritis and Acetaminophen

Effect of Acetaminophen on Osteoarthritis

Acetaminophen, the common brand name for which is Tylenol, can be helpful in relieving some of the pain associated with osteoarthritis.

Acetaminophen should be considered the first-line drug treatment in most osteoarthritis patients.

Read more details about Acetaminophen.

Research Evidence on Acetaminophen

In a study, 80% of patients were unable to distinguish between the effects of sustained-relief acetaminophen and celcoxib for overall symptom improvement.

What are the precautions when taking this medicine?

• Avoid other sources of acetaminophen. An overdose may cause dangerous problems.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Avoid or limit alcohol intake (includes wine, beer, and liquor) to less than 3 drinks a day. Drinking too much alcohol may increase the risk of liver disease.

• If you have PKU, talk with healthcare provider. Some products do contain phenylalanine.

• Be careful if you have G6PD deficiency. Anemia may occur.

• Tell healthcare provider if you are pregnant or plan on getting pregnant.

What are some possible side effects of this medicine?

• Liver damage can rarely occur.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Significant change in thinking clearly and logically.

• Severe belly pain.

• Severe nausea or vomiting.

• Yellow skin or eyes.

• Not able to eat.

• Feeling extremely tired or weak.

• Any rash.

• No improvement in condition or feeling worse.

References

Arthritis Foundation website. Available at: http://www.arthritis.org/ .

Conn’s Current Therapy . 54th ed. WB Saunders Company; 2002.

Drug Facts and Comparisons . 56th ed. Facts & Comparisons; 2001.

Health Library editorial staff and contributors. Medications for fibromyalgia. EBSCO Health Library website. Available at: http://www.ebscohost.com/thisTopic.php?marketID=15topicID=81 . Updated August 6, 2010. Accessed August 27, 2010.

Hydrocodone and acetaminophen. EBSCO Health Library, Lexi-PALS website. Available at: http://www.ebscohost.com/thisTopic.php?marketID=15topicID=81 . Updated March 19, 2010. Accessed August 27, 2010.

Lexi-PALS. Duloxetine. EBSCO Health Library, Lexi-PALS website. Available at: http://www.ebscohost.com/thisTopic.php?marketID=15topicID=81. Updated March 19, 2010. Accessed November 15, 2010.

Manek NJ, Lane NE. Osteoarthritis: current concepts in diagnosis and management. American Family Physician . 2000;51(6). Available at: http://www.aafp.org/afp/20000315/1795.html.

Mayo Clinic. Osteoarthritis: treatments and drugs. Mayo Clinic website. Available at: http://www.mayocli... . Updated July 8, 2010. Accessed August 27, 2010.

National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at: http://www.niams.nih.gov/ .

Propoxyphene. EBSCO Health Library, Lexi-PALS website. Available at: http://www.ebscohost.com/thisTopic.php?marketID=15topicID=81 . Updated March 22, 2010. Accessed August 27, 2010.

3/17/2007 http://www.ebscohost.com/dynamed/what.php : Yelland MJ, Nickles CJ, McNairn N, Del Mar CB, Schluter PJ, Brown RM. Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials. Rheumatology (Oxford). 2007;46:135-140. Epub 2006 Jun.

2/7/2008 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Underwood M, Ashby D, Cross P, et al. Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study. BMJ. 2008;336:138-142. Epub 2007 Dec 4.

10/26/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php: Massey T, Derry S, Moore R, McQuay H. Topical NSAIDs for acute pain in adults. Cochrane Database Syst Rev. 2010;(6):CD007402.

11/15/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php: US Food and Drug

Administration. FDA clears Cymbalta to treat chronic musculoskeletal pain. US Food and Drug Administration website. Available at: http://www.fda.gov.... Published November 4, 2010. Accessed November 12, 2010.

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