Osteoarthritis and Antidepressants
Effect of Antidepressants on Osteoarthritis
Antidepressants may also be prescribed for chronic pain caused by osteoarthritis.
Cymbalta, or duloxetine, is the most commonly prescribed antidepressant for osteoarthritis.
Side Effects and Warnings
The most common side effects associated with trazodone use include: nausea, dizziness, muscle pain, loss of coordination, tiredness, dry mouth, constipaton, headache and blurred vision. Call your doctor immediately if you have any new or worsening symptoms such as: unsual changes in behavior, anxiety, panic attacks, trouble sleeping, or if you
feel impulsive, irritable, agitated, hostile, aggressive, restless, more depressed, or have thoughts about suicide or hurting yourself.
Patients taking trazadone are advised to avoid alcohol. It is also important to inform your doctor about all the prescription and over-the-counter drugs that you are taking. The following drugs may
interact with trazadone:
•indinavir (Crixivan) or ritonavir (Norvir);
•ketoconazole (Nizoral) or itraconazole (Sporanox);
•digoxin (Lanoxin, Lanoxicaps);
•carbamazepine (Carbatrol, Tegretol) or phenytoin (Dilantin);
•MAO inhibitors, such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).
Remeron may cause weight gain, sometimes this may requiring discontinuation of treatment. Mirtazapine may increase cholesterol and triglyceride levels. Other
common side effects include: dizziness, nausea, flu symptoms and constipation. Seek immediate medical attention when you experience any severe side effect such as Severe allergic reactions, mental or mood changes thoughts of hurting yourself, tremors and worsening of depression.
Mirtazapine potentiates the sedating effects of other drugs of drugs that can cause sedation such as the benzodiazepine class of anti-anxiety drugs, the narcotic pain relievers, tricyclic class of antidepressants, certain drugs for hypertension and some antihistamines. Mirtazapine should not be used with MAO inhibitors such as selegilin (Carbex), phenelzine (Nardil), furazolidone (Furoxone), procarbazine (Matulane), or tranylcypromine (Parnate). Avoid drinking alcohol because it may worsen some of the
side effects of mirtzapine.
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