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Osteoarthritis and Nonsteroidal Anti-inflammatory Agents (NSAIDs)

Written by sshowalter.

Effect of Nonsteroidal Anti-inflammatory Agents (NSAIDs) on Osteoarthritis

Nonsteroidal anti-inflammatory drugs (NSAIDs) help decrease inflammation, swelling, and joint pain which are the major symptoms of osteoarthritis. Many NSAIDs are available over-the-counter. You may be given a prescription for a higher dose. Topical pain medications (eg, creams, patches) are another option.

The following are among the most common examples for NSAIDs prescribed for the treatment of Osteoarthritis.

  • Naproxen (Naprosyn, Anaprox, Aleve)
  • Ketoprofen (Orudis)
  • Ibuprofen (Motrin, Advil, Nuprin)
  • Indomethacin (Indocin)
  • Sulindac (Clinoril)
  • Meclofenamate (Meclomen)
  • Ketorolac (Toradol)
  • Piroxicam (Feldene)
  • Diclofenac (Voltaren, Cataflam)

Read more details about Nonsteroidal Anti-inflammatory Agents (NSAIDs).

Drinking alcoholic beverages or taking other NSAIDs while you are already using an NSAID can increase your risk of side effects. Always take NSAIDs with food to decrease the chance of stomach irritation.

Possible side effects include:

  • Stomach upset
  • Stomach ulcers
  • Kidney damage
  • Liver inflammation
  • Confusion, dizziness, lightheadedness
  • Severe allergic reaction (hives, difficulty breathing, swelling around the eyes)
  • Increased risk of bleeding – Always inform your healthcare providers that you are taking an NSAID before having any medical or dental procedures or surgeries.

Take special care with NSAIDs if you have had an ulcer or gastritis, as they can irritate these conditions. Tell your doctor if you have a stomach condition before you start taking any of these medications.

References

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Drug Facts and Comparisons . 56th ed. Facts & Comparisons; 2001.

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Hydrocodone and acetaminophen. EBSCO Health Library, Lexi-PALS website. Available at: http://www.ebscohost.com/thisTopic.php?marketID=15topicID=81 . Updated March 19, 2010. Accessed August 27, 2010.

Lexi-PALS. Duloxetine. EBSCO Health Library, Lexi-PALS website. Available at: http://www.ebscohost.com/thisTopic.php?marketID=15topicID=81. Updated March 19, 2010. Accessed November 15, 2010.

Manek NJ, Lane NE. Osteoarthritis: current concepts in diagnosis and management. American Family Physician . 2000;51(6). Available at: http://www.aafp.org/afp/20000315/1795.html.

Mayo Clinic. Osteoarthritis: treatments and drugs. Mayo Clinic website. Available at: http://www.mayocli... . Updated July 8, 2010. Accessed August 27, 2010.

National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at: http://www.niams.nih.gov/ .

Propoxyphene. EBSCO Health Library, Lexi-PALS website. Available at: http://www.ebscohost.com/thisTopic.php?marketID=15topicID=81 . Updated March 22, 2010. Accessed August 27, 2010.

3/17/2007 http://www.ebscohost.com/dynamed/what.php : Yelland MJ, Nickles CJ, McNairn N, Del Mar CB, Schluter PJ, Brown RM. Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials. Rheumatology (Oxford). 2007;46:135-140. Epub 2006 Jun.

2/7/2008 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Underwood M, Ashby D, Cross P, et al. Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study. BMJ. 2008;336:138-142. Epub 2007 Dec 4.

10/26/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php: Massey T, Derry S, Moore R, McQuay H. Topical NSAIDs for acute pain in adults. Cochrane Database Syst Rev. 2010;(6):CD007402.

11/15/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php: US Food and Drug

Administration. FDA clears Cymbalta to treat chronic musculoskeletal pain. US Food and Drug Administration website. Available at: http://www.fda.gov.... Published November 4, 2010. Accessed November 12, 2010.

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