Oxaliplatin Side Effects and Warnings

What are the precautions when taking this medicine?

• If you have kidney disease, talk with healthcare provider.

• If you have liver disease, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Talk with healthcare provider before receiving any vaccinations. Use with this medicine may either increase the risk of serious infection or make the vaccination less effective.

• Talk with healthcare provider before using other: aspirin, aspirin-containing products, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain medicines, or vitamin E.

• Avoid cold temperatures, cold foods or drinks, cold flooring, and refrigerator or freezer for at least 5 days after medicine is given.

• Tell dentists, surgeons, and other healthcare providers that you use this medicine.

• You may not be alert. Avoid driving, doing other tasks or activities until you see how this medicine affects you.

• You may bleed more easily. Be careful. Avoid injury. Use soft toothbrush, electric razor.

• If you are a male and sexually active, protect your partner from pregnancy during treatment and for 6 months after treatment ends. Use birth control that you can trust.

What are some possible side effects of this medicine?

• Numbness and tingling of feet or hands caused by exposure to cold. Avoid cold temperatures, cold food or drinks, cold flooring, and refrigerator or freezer for at least 5 days after medicine is given.

• Throat tightness, feeling unable to swallow or breathe. This goes away by itself. Avoid anything cold for at least 5 days after medicine is given.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Diarrhea.

• Headache.

• Cough.

• Mouth irritation. Frequent mouth care with a soft toothbrush or cotton swabs and rinsing mouth may help.

• Constipation.

• Belly pain.

• Anemia, low white blood cell count, and low platelet count.

• Fever.

• Feeling tired or weak.

• Liver damage can rarely occur.

• Lung damage can rarely occur.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.

• Difficulty breathing.

• Difficulty swallowing.

• Difficulty walking.

• Difficulty doing activities of daily living such as doing up buttons or zippers or opening tops of products.

• Severe dizziness or passing out.

• Persistent cough.

• Severe nausea or vomiting.

• Severe diarrhea.

• Numbness or tingling of hands or feet.

• Sudden change or loss of vision.

• Unusual bruising or bleeding.

• Dark urine or yellow skin or eyes.

• Not able to eat.

• Feeling extremely tired or weak.

• Severe mouth irritation.

• Any rash.

• No improvement in condition or feeling worse.