Progesterone
What is it? Overview Usage Side Effects and Warnings
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Progesterone Usage

Written by FoundHealth.

Therapeutic Uses

Progesterone cream was widely promoted in the 1990s a treatment for osteoporosis , on the basis of meaningless “studies” whose designs were too poor to establish anything at all. 1 2 When properly designed studies were performed, the results were at best inconsistent. 3 Studies conflict on whether progesterone cream can help hot flashes. 4 One double-blind, placebo-controlled study failed to find any improvements in mood or general well-being in menopausal women using progesterone cream. 5 Like progestins, oral progesterone protects the uterus from the stimulating effects of unopposed estrogen. However, standard doses of progesterone cream probably provide too little progesterone to serve for this purpose (see next section).

References

  1. Lee JR. Is natural progesterone the missing link in osteoporosis prevention and treatment? Med Hypotheses. 35(4):316-8.
  2. Lee JR. Osteoporosis reversal with transdermal progesterone. Lancet. 336(8726):1327.
  3. Leonetti HB, Longo S, Anasti JN. Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstet Gynecol. 94(2):225-8.
  4. Leonetti HB, Longo S, Anasti JN. Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstet Gynecol. 94(2):225-8.
  5. Wren BG, Champion SM, Willetts K, Manga RZ, Eden JA. Transdermal progesterone and its effect on vasomotor symptoms, blood lipid levels, bone metabolic markers, moods, and quality of life for postmenopausal women. Menopause. 10(1):13-8.
 
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