S-Adenosylmethionine (SAMe):
What is it?

S-Adenosylmethionine (SAMe):
How is it Used?

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S-Adenosylmethionine (SAMe) Side Effects and Warnings

Side Effects and Warnings

#Safety Issues

SAMe appears to be quite safe, according to both human and animal studies. ^[1] ^[2] ^[3] ^[4] The most common side effect is mild digestive distress. However, SAMe does not actually damage the stomach. ^[5] Like other substances with antidepressant activity, SAMe might trigger a manic episode in those with bipolar disease (manic-depressive illness). ^[7] ^[8] Safety in young children, pregnant or nursing women, or those with severe liver or kidney disease has not been established.

SAMe might interfere with the action of the Parkinson's drug levodopa. ^[9] In addition, there may also be risks involved in combining SAMe with standard antidepressants. ^[10] For this reason, you shouldn't try either combination except under physician supervision.

#Interactions You Should Know About

If you are taking:

  • Standard antidepressants, including MAO inhibitors , SSRIs , and tricyclics : Do not take SAMe except on a physician's advice.
  • Levodopa for Parkinson's disease: SAMe might help relieve the side effects of this drug. However, it might also reduce its effectiveness over time.