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Occasional effects may occur with sting nettle use, these include mild stomach upset, fluid retention, and skin rashes.
Incidence of serious allergic reactions to stinging nettle use is quite rare. You should stop taking stinging nettle and seek emergency care if you develop signs and symptoms of allergic reaction such as throat tightness, wheezing, difficulty breathing, swelling of tongue, lips or face, and skin reactions such as hives, redness, sense of warmth, itching.
Stinging nettle may potentiate the action or interact with certain drugs such as blood thinners, blood pressure medications, drugs for diabetes, and some pain killers. Talk to your doctor before taking nettle if you are taking any prescription drugs or supplements.