Vitamin B3:
What is it?

Vitamin B3:
How is it Used?

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Vitamin B3 Usage


Effect of Vitamin B3 on Acne

Niacinamide gel might help treat acne by addressing the infection and inflammation associated with the condition.

Read more about Acne and Niacinamide Gel.

Effect of Vitamin B3 on Lipid Disorders

Niacin can have a number of favorable effects on serum (blood) lipids--it reduces bad cholesterol, increases good cholesterol, and reduces triglycerides. It probably reduces levels of bad cholesterol...

Read more about Lipid Disorders and Vitamin B3.

Therapeutic Uses

There is no question that niacin (but not niacinamide) can significantly improve cholesterol profile, reducing levels of total and LDL ("bad") cholesterol and raising HDL ("good") cholesterol. ^[2] ^[3] ^[4] ^[5] ^[6] ^[7] ^[8] However, unpleasant flushing reactions as well as a risk of liver inflammation and dangerous interactions with other cholesterol-lowering drugs have kept niacin from being widely used (see Safety Issues ).

Niacinamide may improve blood sugar control in both children and adults who already have diabetes. ^[9] In addition, some evidence had suggested that regular use of niacinamide (but not niacin) might help preventdiabetes in children at special risk of developing it; ^[11] unfortunately, subsequent studies indicate that it probably does not work. ^[12] Preliminary evidence suggests that niacinamide may be able to decrease symptoms of osteoarthritis ^[14] and help control polymorphous light eruption, a type of photosensitivity . ^[16] Somewhat surprisingly, topicalniacinamide has shown some promise for skin conditions. In a double-blind study of 50 women with signs of aging skin , use of a niacinamide cream significantly improved skin appearance and elasticity as compared to placebo cream. ^[18] Niacinamide cream has also shown promise for rosacea . ^[20] The inositol hexaniacinate form of niacin (taken orally) may be helpful for intermittent claudication ^[22] and Raynaud's phenomenon . ^[24]

In addition, weak and in some cases contradictory evidence suggests one of the several forms of niacin might be helpful for people with bursitis , ^[26] cataracts , ^[28] HIV infection, ^[30] pregnancy , ^[32] schizophrenia , ^[34] ^[35] ^[36] ^[37] ^[38] ^[39] and tardive dyskinesia . ^[41] A new use of niacin was reported in 2007: it appears that some people take very high doses of niacin (in the neighborhood of 2.5 to 5 grams at a time ) in the belief that it will mask drugs in the urine. ^[42] However, not only does niacin fail to conceal the presence of drugs on a urine drug screen, when taken suddenly at doses this high, niacin can cause life-threatening problems involving the liver and heart. In addition, it can dangerously disturb blood sugar regulation and blood coagulation.