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Glucosamine appears to be a generally safe treatment and has not been associated with significant side effects. A few case reports and animal studies raised concerns that glucosamine might raise blood sugar in people with diabetes, but subsequent studies have tended to lay these concerns to rest. 1 Glucosamine does not appear to affect cholesterol levels either. 2 There is one case report of an allergic reaction to a glucosamine/chondroitin product, causing exacerbation of asthma . 3
- Shankar RR, Zhu JS, Baron AD. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus. Metabolism. 47(5):573-7.
- Ostergaard K, Hviid T, Hyllested-Winge JL. The effect of glucosamine sulphate on the blood levels of cholesterol or triglycerides—a clinical study. Ugeskr Laeger. 2007;169:407-410.
- Yu JG, Boies SM, Olefsky JM. The effect of oral glucosamine sulfate on insulin sensitivity in human subjects. Diabetes Care. 26(6):1941-2.