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There are no indications that P. amarus is toxic when used at recommended doses, but comprehensive safety studies have not been performed. 1 In double-blind studies, significant side effects have not been reported. Safety in pregnant or nursing women, or individuals with severe liver or kidney disease, has not been established.
- Thyagarajan SP, Subramanian S, Thirunalasundar T, et al. Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. Lancet. 1988;2:764–766.