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Effect of Alprostadil on Erectile Dysfunction
There are two types of alprostadil:
- Transurethral alprostadil (MUSE)
- Intracavernosal alprostadil (Caverject, Edex)
Alprostadil acts directly on the blood vessels in the penis to cause an erection. It can be inserted into the urethra (urinary tube in the penis) with a special device or injected with a small needle. Erection occurs in 8-10 minutes and lasts 30-60 minutes. The injection is effective in about 65%-85% of users; the insert is effective in about 65%. The maximal number of injections per week is three.
Read more details about Alprostadil.
What are the precautions when taking this medicine?
• Do not donate blood while using this medicine and for 1 month after stopping.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Avoid alcohol (includes wine, beer, and liquor).
• To protect against sexually-transmitted diseases, use a latex condom.
• Muse®: Use a condom when having sex with a pregnant woman.
What are some possible side effects of this medicine?
• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
• Penile pain.
• Irritation where the medicine is given.
Reasons to call healthcare provider immediately
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Penile erection that lasts longer than 4 hours.
• Chest pain or pressure or fast heartbeat.
• Severe dizziness or passing out.
• Difficulty breathing.
• Severe penile pain.
• Unusual bruising or bleeding.
• Severe skin irritation.
• Any rash.
• No improvement in condition or feeling worse.
American Academy of Family Physicians website. Available at: http://www.aafp.org/online/en/home.html .
Guay AT, Spark RF, Bansal S, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of male sexual dysfunction: a couple’s problem: 2003 update. Endocr Pract. 2003;9:77-95.
McMahon CN. Treating erectile dysfunction when PDE5 inhibitors fail. Brit Med J. 2006;332:589-592.
Montorsi F, Padma-Nathan H, Gilina S. Erectile function and assessments of erection hardness correlate positively with measures of emotional well-being, sexual satisfaction, and treatment satisfaction in men with erectile dysfunction treated with sildenafil citrate (Viagra). Urology. 2006;68:26-37.
Nonsurgical management of erectile dysfunction (ED). American Urological Association Foundation website. Available at: http://www.urologyhealth.org/adult/index.cfm?cat=11&topic=174 . Accessed August 8, 2010.
Sivalingam S, Hashim H, Schwaibold H. An overview of the diagnosis and treatment of erectile dysfunction. Drugs. 2006;66:2339-2355. Webber R. Erectile dysfunction. Clinical Evidence. 2005;13:1120-1127.
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