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Artichoke leaf has not been associated with significant side effects in studies so far, but full safety testing has not been completed. For this reason, it should not be used by pregnant or nursing women. Safety in young children or in people with severe liver or kidney disease has also not been established.
In addition, because artichoke leaf is believed to stimulate gallbladder contraction, individuals with gallstones or other forms of gallbladder disease could be put at risk by using this herb. Such individuals should use artichoke leaf only under the supervision of a physician. It is possible that increased gallbladder contraction could lead to obstruction of ducts or even rupture of the gallbladder.
Finally, individuals with known allergies to artichokes or related plants in the Asteraceae family, such as arnica or chrysanthemums, should avoid using artichoke or cynarin preparations.