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Biologic Response Modifiers
What is it? Overview Usage Side Effects and Warnings

Biologic Response Modifiers Side Effects and Warnings

Written by ColleenO.

All patients receiving biologic response modifiers must first undergo a skin test for tuberculosis, a chest x-ray, a complete blood count, as well as blood tests for liver and kidney function. Certain blood tests will continue to be monitored throughout the course of treatment.

Possible side effects include:

  • Chills
  • Headache
  • Fever
  • Nausea
  • Muscular pain or tenderness
  • Injection site reactions

Serious complications may include:

  • Allergic reactions
  • Serious infections
  • Blood-related cancers
  • Low platelets
  • Severe, immune-mediated anemia
  • Arthritis events
  • Psoriasis worsening
  • Lupus-like reactions
  • Multiple sclerosis-like reactions
  • Increased risk for children and teens to develop Hodgkin’s and non-Hodgkin’s lymphoma and other types of cancer


  • Known chronic infections
  • Allergy to any of the medication components
  • Low white blood cell counts


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