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Blessed thistle has a long history of use in European herbal medicine. All parts of the above-ground plant are used medicinally. The herb was used primarily for digestive problems, including heartburn, gastritis, burping, constipation, and flatulence. Blessed thistle was also used for liver and gallbladder diseases. Blessed thistle is also a component of the famous herbal combination therapy Essiac, widely used (though without scientific support) as a treatment for cancer .
A typical dose of blessed thistle is 2 grams two or three times daily.