Bortezomib Side Effects and Warnings

What are the precautions when taking this medicine?

• If you have diabetes, talk with healthcare provider.

• If you have heart disease, talk with healthcare provider.

• If you have high blood pressure, talk with healthcare provider.

• If you have liver disease, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Do not take St John's wort with this medicine. It may make this medicine less effective.

• Avoid grapefruit and grapefruit juice.

• Avoid multivitamins, natural products, and dietary supplements that contain additional vitamin C.

• Avoid green tea and green tea extracts.

• Use birth control that you can trust to prevent pregnancy while taking this medicine.

What are some possible side effects of this medicine?

• Low white blood cell count or low platelet count.

• Blurred vision. Use caution when driving or doing other tasks that require you to have clear vision.

• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative.

• Diarrhea.

• Low blood pressure.

• Anemia.

• Viral infection.

• Fever.

• Feeling tired or weak.

• Muscle pain.

• Headache.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Severe dizziness or passing out.

• Numbness or tingling of hands or feet.

• Difficulty breathing.

• Sudden change in vision.

• Severe nausea or vomiting.

• Severe diarrhea.

• Not able to eat.

• Persistent cough.

• Severe swelling.

• Feeling extremely tired or weak.

• Significant change in thinking clearly and logically.

• Unusual bruising or bleeding.

• Any rash.

• No improvement in condition or feeling worse.