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Therapeutic Uses
Preliminary evidence suggests that BCAAs may improve appetite in people undergoing treatment for cancer . 1 There is also some evidence that BCAA supplements may reduce symptoms of amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease); however, not all studies have had positive results. 2 3 4 Preliminary evidence from a series of small studies suggests that BCAAs might decrease symptoms of tardive dyskinesia , a movement disorder caused by long-term usage of antipsychotic drugs. 5 BCAAs have also shown a bit of promise for enhancing recovery from traumatic brain injury. 6 Because of how they are metabolized in the body, BCAAs might be helpful for individuals with severe liver disease (such as cirrhosis ). 7 BCAAs have also been tried for aiding muscle recovery after bedrest, such as following surgery . 8 Although there is a little supportive evidence, on balance, current research does notindicate that BCAAs are effective as a for enhancing sports performance . 9 One preliminary study hints that BCAAs might aid recovery from long distance running. 10 BCAAs have also as yet failed to prove effective for muscular dystrophy. 11
References
- Cangiano C, Laviano A, Meguid MM, Mulieri M, Conversano L, Preziosa I, Rossi-Fanelli F. Effects of administration of oral branched-chain amino acids on anorexia and caloric intake in cancer patients. J Natl Cancer Inst. 88(8):550-2.
- Plaitakis A, Smith J, Mandeli J, Yahr MD. Pilot trial of branched-chain aminoacids in amyotrophic lateral sclerosis. Lancet. 1(8593):1015-8.
- Testa D, Caraceni T, Fetoni V. Branched-chain amino acids in the treatment of amyotrophic lateral sclerosis. J Neurol. 236(8):445-7.
- Tandan R, Bromberg MB, Forshew D, Fries TJ, Badger GJ, Carpenter J, Krusinski PB, Betts EF, Arciero K, Nau K. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology. 47(5):1220-6.
- Richardson MA, Bevans ML, Weber JB, Gonzalez JJ, Flynn CJ, Amira L, Read LL, Suckow RF, Maher TJ. Branched chain amino acids decrease tardive dyskinesia symptoms. Psychopharmacology (Berl). 143(4):358-64.
- Crowe MJ, Weatherson JN, Bowden BF. Effects of dietary leucine supplementation on exercise performance. Eur J Appl Physiol. 97(6):664-72.
- Marchesini G, Bianchi G, Rossi B, Brizi M, Melchionda N. Nutritional treatment with branched-chain amino acids in advanced liver cirrhosis. J Gastroenterol. 35 Suppl 12():7-12.
- Stein TP, Donaldson MR, Leskiw MJ, Schluter MD, Baggett DW, Boden G. Branched-chain amino acid supplementation during bed rest: effect on recovery. J Appl Physiol. 94(4):1345-52.
- Kelly GS. Sports nutrition: a review of selected nutritional supplements for bodybuilders and strength athletes. Alt Med Rev. 1997;2:184-201.
- Crowe MJ, Weatherson JN, Bowden BF. Effects of dietary leucine supplementation on exercise performance. Eur J Appl Physiol. 97(6):664-72.
- Mendell JR, Griggs RC, Moxley RT III, et al. Clinical investigation in Duchenne muscular dystrophy: IV. Double-blind controlled trial of leucine. Muscle Nerve. 1984;7:535-541.