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Calendula is generally regarded as safe. Neither calendula cream nor calendula taken internally has been associated with any adverse effects other than occasional allergic reactions, and animal studies have found no significant toxic effects. 1 However, the same studies found that in high doses, calendula acts like a sedative and also reduces blood pressure. For this reason, it might not be safe to combine calendula with sedative or blood pressure medications.
Interactions You Should Know About
If you are taking
- Sedative drugs:Calendula might increase the sedative effect.
- Medications to reduce blood pressure:Internal use of calendula might amplify the blood pressure-lowering effect.
- Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof. 1964;43:15–20.