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Because cartilage is just common, ordinary gristle, it is presumably safe to consume. However, for reasons that are not at all clear at this time, there is a report of an individual who developed liver inflammation after taking shark cartilage supplements. 1 He recovered fully when the supplements were discontinued.
- Ashar B, Vargo E. Shark cartilage-induced hepatitis. Ann Intern Med. 125(9):780-1.