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What is it? Overview Usage Side Effects and Warnings

Cayenne Side Effects and Warnings

Written by FoundHealth.

Safety Issues

Capsaicin creams commonly cause an unpleasant burning sensation when they are first applied; this sensation disappears over subsequent days as treatment is continued.

As a commonly used food, cayenne is generally recognized as safe. Contrary to some reports, cayenne does not appear to aggravate stomach ulcers . 1

Interactions You Should Know About

If you are taking:

  • The asthma drug theophylline : Cayenne might increase the amount you absorb, possibly leading to toxic levels. 2
  • Nonsteroidal anti-inflammatory drugs : Cayenne might protect your stomach from damage.


  1. Graham DY, Smith JL, Opekun AR. Spicy food and the stomach. Evaluation by videoendoscopy. JAMA. 260(23):3473-5.
  2. Bouraoui A, Toumi A, Mustapha HB, et al. Effects of capsicum fruit on theophylline absorption and bioavailability in rabbits. Drug Nutr Interact. 1998;5:345-350.


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