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Cetylated Fatty Acids
What is it? Overview Usage Side Effects and Warnings

Cetylated Fatty Acids Usage

Written by FoundHealth.


Effect of Cetylated Fatty Acids on Osteoarthritis

A type of naturally occurring fatty acid called cetylated fatty acids have shown growing promise for osteoarthritis. It is used both as a topical cream and as an oral supplement.

It's not known how...

Read more about Osteoarthritis and Cetylated Fatty Acids.

Therapeutic Uses

Three double-blind, placebo-controlled studies have found cetylated fatty acids helpful for osteoarthritis . Two involved a topical product, and one used an oral formulation.

In one of the studies using that used a cream preparation, 40 people with osteoarthritis of the knee applied either cetylated fatty acids or placebo to the affected joint. 1 The results over 30 days showed greater improvements in range of motion and functional ability among people using the real cream than those using the placebo cream.

In another 30-day study, also enrolling 40 people with knee arthritis, use of cetylated fatty acid cream improved postural stability, presumably due to decreased pain levels. 2 In addition, a 68-day, double-blind, placebo-controlled study of 64 people with knee arthritis tested an oral cetylated fatty acid supplement (the supplement also contained lesser amounts of lecithin and fish oil .) 3 Participants in the treatment group experienced improvements in swelling, mobility, and pain level as compared to those in the placebo group. Inexplicably, the study report does not discuss whether or not side effects occurred.

While this is a promising body of research, it is far from definitive. Current advertising claims for cetylated fatty acids go far beyond the existing evidence. For example, a number of websites claim that cetylated fatty acids are more effective than glucosamine or chondroitin . However, no comparison studies have been performed upon which such a claim could be rationally based.

It's not known how cetylated fatty acids might help osteoarthritis. Proponents cite the known benefits of fish oil for rheumatoid arthritis , but since the fatty acids in fish oil are rather different from those in cetylated fatty acids, and the origin of rheumatoid arthritis is quite unlike that of osteoarthritis, there is little relevance to these observations. Proponents also make multiple specific claims, including that cetylated fatty acids reduce inflammation, protect cartilage from damage, lubricate cell membranes, and increase fluid in joints. However, none of these explanations have more than speculative scientific support. At present, if in fact cetylated fatty acids help osteoarthritis, we do not know how they might do so.

Cetylated fatty acid creams have also been proposed for treatment of psoriasis . 4


  1. Kraemer WJ, Ratamess NA, Anderson JM, Maresh CM, Tiberio DP, Joyce ME, Messinger BN, French DN, Rubin MR, Gómez AL, Volek JS, Hesslink R Jr. Effect of a cetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis. J Rheumatol. 31(4):767-74.
  2. Kraemer WJ, Ratamess NA, Maresh CM, Anderson JA, Tiberio DP, Joyce ME, Messinger BN, French DN, Sharman MJ, Rubin MR, Gómez AL, Volek JS, Silvestre R, Hesslink RL Jr. Effects of treatment with a cetylated fatty acid topical cream on static postural stability and plantar pressure distribution in patients with knee osteoarthritis. J Strength Cond Res. 19(1):115-21.
  3. Hesslink R Jr, Armstrong D 3rd, Nagendran MV, Sreevatsan S, Barathur R. Cetylated fatty acids improve knee function in patients with osteoarthritis. J Rheumatol. 29(8):1708-12.
  4. A preliminary study for the use of Celadrin™ for the treatment of psoriasis. Available at: Issues. Accessed June 3, 2005.


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