Chelation Therapy
What is it? Overview Usage Side Effects and Warnings

Chelation Therapy Overview

How It Works

The chelating solution contains EDTA and vitamins and minerals and is administered intravenously. The treatment can last 20 to 30 minutes and may be recommended once to several times per week.

To ensure its safety, the health care professional will administer a number of tests before, during, and after the treatment.


When medical researchers first investigated the phenomenon known as hardening of the arteries (closely related to atherosclerosis ), they discovered that the damaged, brittle vessels found in people with heart disease were lined with calcium deposits. Naturally, this finding inspired the notion that calcium deposits were the cause of the problem.

Some early researchers investigated the possible therapeutic effect of removing such deposits. However, subsequent research indicated that the calcium deposits of atherosclerosis were a symptom rather than a cause, and mainstream interest turned elsewhere. Certain physicians nonetheless maintained an interest in removing calcium; thus chelation therapy was born.

Chelation therapy for heart disease consists of intravenous infusions of a chemical called EDTA (ethylenediaminetetraacetic acid). This synthetic substance is used in conventional medicine to remove heavy metals, such as lead, from the body, but it also has an effect on calcium, which is why it came into use in chelation therapy.

Proponents claim that EDTA chelation is an effective alternative to heart surgery, and that it also offers many other health benefits. To support this, they cite numerous anecdotes of cures apparently brought about by its use. However, anecdotes cannot possibly prove a treatment effective. Only double-blind, placebo-controlled trials can do so, and thus far such studies have failed to find chelation therapy effective.

In 2000, a highly respected researcher reviewed the literature on chelation therapy and concluded, “The most striking finding is the almost total lack of convincing evidence for efficacy…. Only 2 controlled clinical trials were located. They provide no evidence that chelation therapy is efficacious beyond a powerful placebo effect…. Given the potential of chelation therapy to cause severe adverse effects, this treatment should now be considered obsolete.” 1 Subsequent to this review, a well-designed study compared chelation therapy to placebo in 84 people with coronary artery disease. 2 People receiving EDTA chelation showed improvement; however, those receiving placebo also improved—to the same extent! This finding reminds us why double-blind, placebo-controlled studies are necessary to establish the effectiveness of a treatment. If researchers had performed this study without a placebo group, they might have concluded that EDTA chelation really works. Instead, the fact that the same level of benefits was seen in the fake-treatment group indicates that chelation therapy does not work.

Another double-blind study evaluated the potential benefits of chelation therapy when added to conventional therapy in the treatment of people with coronary artery disease. 3 Researchers were looking for improvements in the ability of a blood vessel in the arm (the brachial artery) to dilate, but did not find any. However, this study had several limitations in its design, making its results less meaningful than they might have been.


  1. Ernst E. Chelation therapy for coronary heart disease: An overview of all clinical investigations. Am Heart J. 140(1):139-41.
  2. Knudtson ML, Wyse DG, Galbraith PD, Brant R, Hildebrand K, Paterson D, Richardson D, Burkart C, Burgess E, Program to Assess Alternative Treatment Strategies to Achieve Cardiac Health (PA. Chelation therapy for ischemic heart disease: a randomized controlled trial. JAMA. 287(4):481-6.
  3. Anderson TJ, Hubacek J, Wyse DG, Knudtson ML. Effect of chelation therapy on endothelial function in patients with coronary artery disease: PATCH substudy. J Am Coll Cardiol. 41(3):420-5.


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