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Modifying your diet to make it more healthful should have few, if any, side effects. If you have a serious health condition, consult with your physician or another trusted health provider before you make any drastic changes.
A low-fat, high-carbohydrate diet might actually increase triglycerides. If you have high triglycerides, you might do better on a low-carbohydrate diet. Talk to your doctor about the right kind of diet for you.