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Chronic Fatigue Syndrome (CFS) and Echinacea

Written by sshowalter, FoundHealth.

Effect of Echinacea on Chronic Fatigue Syndrome (CFS)

Not yet tested in isolation, echinacea has been studied with panax ginseng and might be helpful in treating chronic fatigue syndrome.

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Research Evidence on Echinacea

A test tube study of echinacea and Panax ginseng found that both increased cellular immune function in cells taken from people with chronic fatigue syndrome.20 However, many herbs and supplements can cause measurable changes in immune function, and such observations do not prove that there will be an actual benefit in people with the disease.

Safety Issues

Echinacea appears to be generally safe. Even when taken in very high doses, it has not been found to cause any toxic effects. 1 Reported side effects are also uncommon and usually limited to minor gastrointestinal symptoms, increased urination, and mild allergic reactions. 2 However, severe allergic reactions have occurred occasionally, some of them life threatening. 3 In Australia, one survey found that 20% of allergy-prone individuals were allergic to echinacea.

Other concerns relate to echinacea’s possible immune-stimulating properties. Immunity is a two-edged sword that the body keeps under careful control; excessively strong immune reactions can be dangerous. Based on this concern, echinacea should be used only with caution (if at all) by individuals with autoimmune disorders, such as multiple sclerosis, lupus, and rheumatoid arthritis.

Furthermore, a recent case report strongly suggests that use of echinacea can trigger episodes of erythema nodosum (EN). 4 EN is an inflammatory condition that involves tender nodules under the skin. These nodules often arise after cold-like symptoms. In this report, a 41-year-old man took echinacea on four separate occasions when he thought he was developing a cold, and each time he developed EN instead. When he stopped using echinacea for this purpose, he remained free of EN outbreaks for a full year of follow-up. The cause of EN is not known, but it involves increased activity of certain immune cells; echinacea has been observed to cause similar effects in the same immune cells, suggesting that the relationship is not coincidental.

One study raised questions about possible antifertility effects of echinacea. 5 When high concentrations of echinacea were placed in a test tube with hamster sperm and ova, the sperm were less able to penetrate the ova. However, since we have no idea whether this much echinacea can actually come in contact with sperm and ova when they are in the body rather than a test tube, these results may not be meaningful in real life.

Animal studies of echinacea are supportive of safety in pregnancy. 6 One human study found a bit of evidence that use of echinacea during pregnancy does not increase risk of birth defects, but this evidence is not strong enough to absolutely rely on. 7 Furthermore, studies dating back to the 1950s suggest that echinacea is safe in children. 8 Nonetheless, the safety of echinacea in young children or pregnant or nursing women cannot be regarded as established. In addition, safety in those with severe liver or kidney disease has also not been established.

Two studies suggest that echinacea might interact with various medications by affecting their metabolism in the liver, but the significance of these largely theoretical findings remain unclear. 9 A review of the research literature found no verifiable reports of drug-herb interactions with any echinacea product. 10


Effect of Ginseng on Chronic Fatigue Syndrome (CFS)

Though not yet tested in isolation, panax ginseng along with echinacea might be helpful in treating chronic fatigue syndrome.

Read more about Chronic Fatigue Syndrome (CFS) and Panax ginseng.


  1. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physicians' Guide to Herbal Medicine. 3rd ed. Berlin, Germany: Springer-Verlag; 1998:276.
  2. Parnham MJ. Benefit-risk assessment of the squeezed sap of the purple coneflower ( Echinacea purpurea ) for long-term oral immunostimulation. Phytomedicine. 1996;3:95-102.
  3. Mullins RJ, Heddle R. Adverse reactions associated with echinacea: the Australian experience. Ann Allergy Asthma Immunol. 88(1):42-51.
  4. Soon SL, Crawford RI. Recurrent erythema nodosum associated with Echinacea herbal therapy. J Am Acad Dermatol. 44(2):298-9.
  5. Ondrizek RR, Chan PJ, Patton WC, King A. An alternative medicine study of herbal effects on the penetration of zona-free hamster oocytes and the integrity of sperm deoxyribonucleic acid. Fertil Steril. 71(3):517-22.
  6. Mengs U, Clare CB, Poiley JA. Toxicity of Echinacea purpurea. Arzneimittelforschung. 1991;41:1076-1081.
  7. Gallo M, Sarkar M, Au W, Pietrzak K, Comas B, Smith M, Jaeger TV, Einarson A, Koren G. Pregnancy outcome following gestational exposure to echinacea: a prospective controlled study. Arch Intern Med. 160(20):3141-3.
  8. Parnham MJ. Benefit-risk assessment of the squeezed sap of the purple coneflower ( Echinacea purpurea ) for long-term oral immunostimulation. Phytomedicine. 1996;3:95-102.
  9. Budzinski JW, Foster BC, Vandenhoek S, et al. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine. 2000;7:273-282.
  10. Freeman C, Spelman K. A critical evaluation of drug interactions with Echinacea spp. Mol Nutr Food Res. 2008 Jul 10.
  1. See DM, Broumand N, Sahl L, et al. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency patients. Immunopharmacology. 1997;35:229-235.

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1 Comment

Posted 13 years ago

I dont know what studies you are refering to but the very few robust good studies showechinacea has no affects

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