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Safety Issues
Extensive investigations of diosmin and hesperidin have found them to be essentially nontoxic and free of drug interactions. 1 The combination has been given to 50 pregnant women in a research study, without apparent harm to mothers or babies. 2 Some evidence suggests that the bioflavonoid naringen may interact with medications in the calcium channel blocker family, increasing blood levels of the drug. 3 This may necessitate a reduction in drug dosage.
The citrus bioflavonoid tangeretin may reduce the effectiveness of tamoxifen , a drug used to treat breast cancer. 4 One highly preliminary study suggests that some citrus bioflavonoids in the diet of pregnant women might increase the risk of infant leukemia; hesperidin did not produce this effect, and diosmin was not tested. 5
Interactions You Should Know About
If you are taking:
- Calcium channel blockers : Use of the bioflavonoid naringen may necessitate a reduction in medication dose.
- Tamoxifen for breast cancer: You should avoid citrus fruits and juices and the citrus bioflavonoid tangeretin.
References
- Meyer OC. Safety and security of Daflon 500 mg in venous insufficiency and in hemorrhoidal disease. Angiology. 45(6 Pt 2):579-84.
- Buckshee K, Takkar D, Aggarwal N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet. 57(2):145-51.
- Yeum CH, Choi JS. Effect of naringin pretreatment on bioavailability of verapamil in rabbits. Arch Pharm Res. 29(1):102-7.
- Bracke ME, Depypere HT, Boterberg T, Van Marck VL, Vennekens KM, Vanluchene E, Nuytinck M, Serreyn R, Mareel MM. Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. J Natl Cancer Inst. 91(4):354-9.
- Strick R, Strissel PL, Borgers S, et al. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc Natl Acad Sci. 2000;97:4790-4795.
